Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Science Advances, 2020
Mattias N. D. Svensson , Martina Zoccheddu, Shen Yang , Gyrid Nygaard, Christian Secchi , Karen M. Doody, Kamil Slowikowski, Fumitaka Mizoguchi , Frances Humby , Rebecca Hands , Eugenio Santelli , Cristiano Sacchetti, Kuninobu Wakabayashi, Dennis J. Wu, Christopher Barback, Rizi Ai , Wei Wang , Gary P. Sims, Piotr Mydel , Tsuyoshi Kasama , David L. Boyle , Francesco Galimi , David Vera , Michel L. Tremblay, Soumya Raychaudhuri , Michael B. Brenner , Gary S. Firestein , Costantino Pitzalis , Anna-Karin H. Ekwall , Stephanie M. Stanford, Nunzio Bottini

Abstract

PTPRS-targeted FLS-directed therapy synergizes with TNF inhibition in therapy of arthritis.

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