Mixed-effects association of single cells identifies an expanded effector CD4+T cell subset in rheumatoid arthritis

Science Translational Medicine, 2018
Chamith Y. Fonseka , Deepak A. Rao , Nikola C. Teslovich , Ilya Korsunsky, Susan K. Hannes , Kamil Slowikowski , Michael F. Gurish, Laura T. Donlin , James A. Lederer, Michael E. Weinblatt, Elena M. Massarotti , Jonathan S. Coblyn, Simon M. Helfgott , Derrick J. Todd , Vivian P. Bykerk , Elizabeth W. Karlson, Joerg Ermann, Yvonne C. Lee , Michael B. Brenner , Soumya Raychaudhuri
PMID: 30333237
PMCID: PMC6448773

Abstract

Mixed-effects regression of single-cell data accounts for confounding variation and reveals an expanded CD4+T cell population in rheumatoid arthritis.

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